I-Hot-melt extrusion (HME) yinkqubo esekiweyo ebisetyenziswa ukusukela kwiminyaka yoo-1930s, ikakhulu kwimveliso yeeplastiki…
Kukho iindidi ezimbini ze-extruders: i-extruders enye kunye ne-twin screw.I-screw extruders enye isetyenziselwa ukunyibilika kunye nokuhambisa iipholima ukuze zikhuphele kwiimilo eziqhubekayo, ngelixa i-twin screw extruders isetyenziselwa ukunyibilika-ukuxuba iipholima ezinemathiriyeli ezongezelelweyo (i-pigments, izihluzi, iziqinisekisi, kunye ne-APIs), kunye ne-devolatilization.Kwimveliso yokwenziwa kwamachiza, efuna ukuxutywa kwe-homo-geneous kunye nokungqinelanayo kwezithako ezininzi zokuqulunqa, i-twin screw extruder ikhethwayo ngenxa yokuba ukujikeleza kwe-screws ye-inter-meshing kunika ukuxuba okungcono ukuvelisa i-homogeneous solid equkethe amaqhekeza e-API ahlakazekileyo, okanye isisombululo esiqinileyo se-API kwipolymer.Oku kunokuphucula izinga lokuchithwa kunye ne-bioavail-ikhono le-API formulations ye-API enganyibiliki kakuhle emanzini.Ukwabiwa ngokulinganayo kwe-API ikwayimfuneko yangaphambili yokuveliswa kwezixhobo zokuhlanjululwa kweziyobisi kunye ne-intra- kunye ne-inter-batch reproducibility ye-chiza-release ki-netics.
Ukunyibilika kufezwa ngokufudumeza kwe-frik-tional ngaphakathi komphanda, kunye ne-twin-screw extruders, njengoko izixhobo zihamba ngokucheba phakathi kwezikrufu ezijikelezayo naphakathi kwezikrufu kunye nodonga lomphanda njengoko zihanjiswa.I-barrel iphinde ifudumale kunye nezifudumezi ezifakwe kwi-barrel, okanye zipholile ngamanzi.Amaqondo obushushu ecandelo lomphanda adla ngokulungiswa ukwenzela ukuba i-viscosity yokunyibilika iphantsi ngokwaneleyo ukuvumela ukuhanjiswa phantsi kombhobho kunye nokuxubana okufanelekileyo, ngelixa ugcina ubushushu obuphantsi ngokwaneleyo ukuphepha ukuthotywa kwe-thermal yezixhobo.
Izikrufu ze-twin screw extruder zihlala zibonelela ngeendidi ezahlukeneyo zokuxuba kunye nokuhambisa iimeko kwiindawo ezahlukeneyo kumbhobho.Ngexesha lophuhliso lwemveliso, izikrufu zemodyuli ezinee-elementi ezininzi ezifakwe kwi-shaft eqhelekileyo, zivumela ukuthungwa kunye nokulungiswa koyilo lwe-screw kwimveliso nganye.Amacandelo e-screw anokuyilwa ukwenza ukunciphisa ubungakanani be-particle, ukuxuba kunye nokuhambisa imisebenzi.Ubude be-screw ngokunxulumene nedayamitha ye-barrel (umlinganiselo we-L / D) ukhethwa ukwandisa iqondo lokuxuba kunye nenani lemimandla efunekayo ukuphumeza imveliso yokugqibela ye-char-acteristics.Umzekelo wesikrufu semodyuli esipheleleyo.Izikrufu zemveliso enye zinokwakhelwa kuyilo olufanayo nezikrufu zophuhliso, kodwa kulula ukuzicoca ukuze kuthotyelwe i-cGMP.
Ixesha lokuthumela: Jun-03-2017